The complex regulatory mechanisms of the BCL-2 family of proteins in cancer

GJ Greaves
Resistance to apoptosis is a key hallmark of most cancers. The BCL-2 family of proteins are the major arbiters of the cell death program and the interactions between pro- and anti-apoptotic members of this family are believed to shift the fate of a cell towards life or death. The anti-apoptotic BCL-2 family proteins (BCL-2, BCL-XL, MCL-1, BCL-w and BCL-2A1) are often overexpressed in cancer, thereby promoting abnormal cell survival. As a result, these proteins are...
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