Characterisation of USP31- the 3rd microtubule localising Deubiquitylase

E Bertsoulaki
Ubiquitylation is a reversible modification with a variety of roles ranging from governing protein homeostasis and trafficking to DNA damage and the immune response. A ubiquitin molecule is added on a substrate protein by an orchestrated cascade of reactions performed by the E1, E2 and E3 enzymes, while it is removed by the Deubiquitylases (DUBs). This work reports for the first time on a hitherto uncharacterised DUB enzyme, USP31. I identified USP31 in a screen...
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