An examination of the endoplasmic reticulum stress response in the filamentous fungus Aspergillus nidulans

ESM Young
Abstract Filamentous fungi are used throughout the biotechnology industry for the production of both native and recombinant proteins. There is a marked difference in the level of recombinant protein production compared to native, with yields decreasing from grams to milligrams per litre. The endoplasmic reticulum stress response (ERSR) has been identified as a potential bottleneck for recombinant protein production. In higher eukaryotes the ERSR has three known sensors, ire1, perk and atf6. Through these sensors,...
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