Exploring the therapeutic potential and cellular mechanisms of BH3 mimetic-mediated apoptosis in cancer

M Milani
Evasion of apoptosis is one of the main hallmarks of cancer. The BCL-2 family of proteins are the main mediators of the intrinsic pathway of apoptosis and the interactions between the pro- and anti-apoptotic members of this family of proteins control the fate of a cell towards life or death. Anti-apoptotic members of the BCL-2 family, such as BCL-2, BCL-XL and MCL-1, are frequently overexpressed in a plethora of cancers promoting abnormal cell survival. During...
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