Investigation into the mechanisms of Stevens-Johnson syndrome and toxic epidermal necrolysis

GB Nwikue
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening immune-mediated blistering cutaneous reactions with mortality rates ranging from 10-30%. The pathophysiological mechanisms of SJS/TEN are complex and not fully understood. However, fulminant keratinocyte death and inflammation have been suggested as the major players in the mechanisms of disease. To further understand the mechanisms of SJS/TEN, we utilised both clinical samples and in vitro human immortalised keratinocyte cell line (HaCaT) cell death models to investigate mediators...
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