Selective labelling of arginine residues in protein sulfated glycosaminoglycan binding sites

TP Bui
In animals, the interaction of numerous proteins with glycosaminoglycans (GAGs) regulates many aspects of their functions, and so organism development and homeostasis, as well many related pathologies. The interactions between the GAG heparan sulfate (HS) and the fibroblast growth factors (FGFs) have become a major paradigm for how such interactions regulate biological outcomes. Thus, binding HS controls FGF stability, its diffusion between cells and the generation of intracellular signals via the cognate FGF receptors (FGFRs)....
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.