The role of ABCB1 and ABCB5 in paediatric inflammatory bowel disease

Anastasia Konidari
ABC transporters play an important role in drug disposition. ABCB1, the most studied representative member of this transporter superfamily, can influence drug response and shape multi-drug resistance in cancer and various diseases including inflammatory bowel disease. Adult studies have shown inter-individual variability in expression between patients with inflammatory bowel disease and healthy controls, which can be modified by corticosteroid administration, a common treatment agent for inflammatory bowel disease. ABCB5 is a novel transporter highly homologous...
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