Host derived markers of lyme disease and other spirochaetal infections: their discovery and diagnostic potential

Greg Joyner
UK laboratory diagnosis of Lyme disease involves the Standard Two-Tier serological approach. The negative predictive value of the test has been challenged, particularly in the early stages of disease. In order to better understand the host response to Lyme disease and to identify any potential host biomarkers that may correlate with early infection, proteomic and transcriptomic analyses were undertaken on Lyme disease patient samples. Label free quantitative spectrometry was used to measure and compare the...
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