ANALYSIS OF BRAFINHIBITOR RESISTANCE IN MELANOMA CELLS

Beth Wilkinson
Malignant melanoma is a highly aggressive and metastatic form of skin cancer with more than 2500 skin cancer related deaths in 2014 in the UK alone. This type of melanoma has a high prevalence of BRAF mutations (90% BRAFV600E) which causes an overactive MAPK signalling cascade leading to excessive proliferation, survival and enhanced angiogenic potential. Vemurafenib and dabrafenib are BRAFV600E specific kinase inhibitors which selectively bind the ATP-binding site supressing ERK activity and inhibits its...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.