The role of non-coding tandem repeat DNA and non-LTR retrotransposons in Amyotrophic Lateral Sclerosis risk loci

Jack Marshall
Genome-wide association studies and functional data have shown that there is a genetic basis contributing to sporadic and familial forms of amyotrophic lateral sclerosis (ALS), with a vast plethora of genes being associated with the disease. Since the discovery of the C9orf72 intronic repeat expansion there has been a growing awareness of non-coding repetitive DNA being associated with ALS risk. Originally labelled “junk DNA”, non-coding repetitive DNA is now known to be vital in regulating...
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