The Physical and Chemical Origins of Amyloid at Interfaces

Nathan Cumberbatch
Amyloidosis is of serious concern within the modern world with an ageing global population, there is a significant drive to understand how amyloid forms in order to research and develop new therapeutics to combat this threat. This thesis proposes using a cross-disciplinary collaborative approach to determine multiple aspects within the amyloid-like fibrillation pathway for human insulin (HI) at acidic and neutral pH conditions. Chapter 2 uses Reflection Anisotropy Spectroscopy to obtain fibrillar orientation information with...
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