The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

Peter Van Galen, Antonija Kreso, Nathan Mbong, David Kent, Timothy Fitzmaurice, Joseph Chambers, Stephanie Xie, Elisa Laurenti, Karin Hermans, Kolja Eppert, Stefan Marciniak, Jane Goodall, Anthony Green, Bradly G Wouters, Erno Wienholds & John E Dick
The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived due to their capacity for self-renewal. A consequence of longevity is exposure to stress stimuli including reactive oxygen species (ROS), nutrient fluctuation and DNA damage. Damage that occurs within stressed HSCs must be tightly controlled to prevent either loss of function or the clonal persistence of oncogenic mutations that increase the risk of leukaemogenesis. Despite the importance of maintaining...
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