Signed-For Delivery in the Mitochondrial Matrix: Confirming Uptake into Mitochondria

Kurt Hoogewijs, Andrew M James, Mike Murphy & Robert N Lightowlers
Mitochondria are best known for their ability to provide energy in the form of an elevated ATP/ADP ratio to the cell via oxidative phosphorylation and, impairment of mitochondrial ATP production can lead to a variety of diseases. For many of these disorders, caused by mutations in the mtDNA, classical gene therapy is not possible due to the to difficulty of importing nucleic acids into the mitochondrial matrix where the aberrant genes are transcribed. Technical progress...
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