Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.

Marc TJ Exton-McGuinness & Amy Milton
Addiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is thought to be driven by maladaptive learning processes which store and maintain associative memory, linking drug highs with cues and actions in the environment. These memories can encode pavlovian associations which link predictive stimuli (e.g. people, places and paraphernalia) with a hedonic drug high, as well as instrumental learning about the actions required to obtain drug-associated incentives. Learned memories are not permanent however,...
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