The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration.

Taxiarchis Katsinelos, Benjamin J Tuck, Aamir S Mukadam & William McEwan
Ordered assemblies of proteins are found in the postmortem brains of sufferers of several neurodegenerative diseases. The cytoplasmic microtubule associated protein tau and alpha-synuclein (αS) are found in an assembled state in Alzheimer’s disease and Parkinson’s disease, respectively. An accumulating body of evidence suggests a “prion-like” mechanism of spread of these assemblies through the diseased brain. Under this hypothesis, assembled variants of these proteins promote the conversion of native proteins to the assembled state. This...
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