Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival.

Liang Wei Wang, Zhonghao Wang, Ina Ersing, Luis Veiga Nobre, Rui Guo, Sizun Jiang, Stephen Trudeau, Bo Zhao, Michael Weekes & Benjamin E Gewurz
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis of multiple lymphomas. Yet, knowledge of how EBV subverts host biosynthetic pathways to transform resting lymphocytes into activated lymphoblasts remains incomplete. Using a temporal proteomic dataset of EBV primary human B-cell infection, we identified that cholesterol and fatty acid biosynthetic pathways were amongst the most highly induced by EBV. Epstein-Barr nuclear antigen 2...
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