Angioimmunoblastic T-cell lymphoma contains multiple clonal T-cell populations derived from a common TET2 mutant progenitor cell.

Wen-Qing Yao, Fangtian Wu, Wenyan Zhang, Shih-Sung Chuang, Joe S Thompson, Zi Chen, Shao-Wei Zhang, Alexandra Clipson, Ming Wang, Hongxiang Liu, Hani Bibawi, Yuanxue Huang, Luis Campos, John W Grant, Penny Wright, Hesham Ei-Daly, Lívia Rásó-Barnett, Lorant Farkas, George A Follows, Zifen Gao, Ayoma D Attygalle, Margaret Ashton-Key, Weiping Liu & Ming-Qing Du
Angioimmunoblastic T-cell lymphoma (AITL) is a neoplastic proliferation of T follicular helper cells with clinical and histological presentations suggesting a role of antigenic drive in its development. Genetically, it is characterized by a step-wise acquisition of somatic mutations, with early mutations involving epigenetic regulators (TET2, DNMT3A) and occurring in haematopoietic stem cells, while subsequent changes involving signaling molecules (RHOA, VAV1, PLCG1, CD28) critical for T-cell biology. To search for evidence of potential oncogenic cooperation between...
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