GDF15 mediates the effects of metformin on body weight and energy balance.

Anthony Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John Alphonse Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A Goldspink, Emily L Miedzybrodzka, Adam R Konopka, Raul Ruiz Esponda, Jeffrey T-J Huang, YC Loraine Tung, Sergio Rodriguez-Cuenca, Rute A Tomaz, Heather Harding, Audrey Melvin, Giles SH Yeo, David Preiss, Antonio Vidal-Puig, Ludovic Vallier, K Sreekumaran Nair … & Stephen O'Rahilly
Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing Type 2 diabetes in people at high risk1,2. Over 60% of this effect is attributable to metformin’s ability to lower body weight in a sustained manner3. The molecular mechanisms through which metformin lowers body weight are unknown. In two, independent randomised controlled clinical trials, circulating levels of GDF15, recently described to reduce food intake and lower body weight through a brain stem-restricted receptor,...
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