The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

Sarah Foerster, Alerie Guzman De La Fuente, Yoshiteru Kagawa, Theresa Bartels, Yuji Owada & Robin Franklin
The major constituents of the myelin sheath are lipids, which are made up of fatty acids (FAs). The hydrophilic environment inside the cells requires FAs to be bound to proteins, preventing their aggregation. Fatty acid binding proteins (Fabps) are one class of proteins known to bind FAs in a cell. Given the crucial role of FAs for myelin sheath formation we investigated the role of Fabp7, the major isoform expressed in oligodendrocyte progenitor cells (OPCs),...
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