Characterization of a Fetal Liver Cell Population Endowed with Long-Term Multi-Organ Endothelial Reconstitution Potential

Ana Cañete, Valentine Comaills, Isabel Prados, Ana María Castro, Seddik Hammad, Patricia Ybot-Gonzalez, Ernesto Bockamp, Jan G Hengstler, Berthold Gottgens & María José Sánchez
Stable reconstitution of vascular endothelial beds upon transplantation of progenitor cells represents an important challenge due to the paucity and generally limited integration/expansion potential of most identified vascular related cell subsets. We previously showed that mouse fetal liver (FL) hemato/vascular cells from day 12 of gestation (E12), expressing the Stem Cell Leukaemia (SCL) gene enhancer transgene (SCL-PLAP$^+$ cells), had robust endothelial engraftment potential when transferred to the blood stream of newborns or adult conditioned recipients,...
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