Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.

Agila Kumari Pragasam, Derek Pickard, Vanessa Wong, Gordon Dougan, Gagandeep Kang, Andrew Thompson, Jacob John, Veeraraghavan Balaji & Ankur Mutreja
Background: Typhoid fever caused by Salmonella Typhi, is a major public health concern in Low and Middle Income countries, with Indian Subcontinent being endemic to the debilitating disease. A recent study of 1900 S. Typhi sampled globally indicated that South Asia might be the site of the original emergence of the most successful and hypervirulent clone belonging to H58/4.3.1 haplotype. However, this study was limited in the number of samples from India. Methods: A total...
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