Age-related retinal thickness in Down's syndrome: A high-risk population for dementia.

Madeleine J Walpert, Eduardo M Normando, Tiina Annus, Sally R Jennings, Liam R Wilson, Peter Watson, Shahid H Zaman, M Francesca Cordeiro & Anthony J Holland
Introduction:People with Down's syndrome (DS) have a high prevalence of early-onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of preventative treatments. The retina, an extension of the brain, may provide a noninvasive imaging site. Methods:Forty-nine adults with DS and 36 age-matched controls completed retinal nerve fibre layer (RNFL) assessments using optical coherence tomography. RNFL thickness was analyzed in relation to cognitive status and age and...
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