Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.

Jonathan Tay, Robin G Morris, Anil M Tuladhar, Masud Husain, Frank-Erik De Leeuw & Hugh Markus
Objective: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods: Analyses used two prospective cohort studies of SVD: St. George's Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in apathy and depression was used to predict dementia in...
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