Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities.

Puja Mehta, Joanna C Porter, Jessica J Manson, John D Isaacs, Peter JM Openshaw, Iain B McInnes, Charlotte Summers & Rachel C Chambers
The COVID-19 pandemic is a global public health crisis, with considerable mortality and morbidity exerting pressure on healthcare resources, including critical care. An overexuberant host inflammatory response, in a subgroup of patients with severe COVID-19 may contribute to the development of acute respiratory distress syndrome (ARDS) and multi-organ failure. Timely therapeutic intervention with immunomodulation in a putative “window of opportunity” in COVID-19 patients with hyperinflammation, may prevent disease progression to ARDS and obviate the need...
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