PI3Kδ inhibition reshapes follicular lymphoma-immune microenvironment cross talk and unleashes the activity of venetoclax.

Neus Serrat, Martina Guerrero-Hernández, Alba Matas-Céspedes, Anella Yahiaoui, Juan G Valero, Ferran Nadeu, Guillem Clot, Miriam Di Re, Marc Corbera-Bellalta, Laura Magnano, Alfredo Rivas-Delgado, Anna Enjuanes, Silvia Beà, Maria C Cid, Elías Campo, Joan Montero, Daniel Hodson, Armando López-Guillermo, Dolors Colomer, Stacey Tannheimer & Patricia Pérez-Galán
Despite idelalisib approval in relapsed follicular lymphoma (FL), a complete characterization of the immunomodulatory consequences of PI3K􀁇 inhibition, biomarkers of response andpotential combinatorial therapies in FL remain to be established. Using ex vivo co-cultures of FL patient biopsies and follicular dendritic cells (FDC) to mimic germinal center (n=42), we have uncovered that PI3K􀁇 inhibition interferes with FDC-induced genes related to angiogenesis, extracellular matrix formation and transendothelial migration in a subset of FL samples, defining a...
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