Improvement of cryo-EM maps by density modification.

Thomas C Terwilliger, Steven J Ludtke, Randy Read, Paul D Adams & Pavel V Afonine
A density modification procedure for improving maps from single-particle electron cryo-microscopy is presented. The theoretical basis of the method is identical to that of maximum-likelihood density modification, previously used to improve maps from macromolecular X-ray crystallography. Key differences from applications in crystallography are that the errors in Fourier coefficients are largely in the phases in crystallography but in both phases and amplitudes in electron cryo-microscopy, and that half-maps with independent errors are available in electron...
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