Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways.

Laura Dearden, S Buller, IC Furigo, Denise Twinn & Susan Ozanne
Objective: Perinatal exposure to maternal obesity results in predisposition of offspring to develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity is usually associated with hyperphagia, implicating altered central regulation of food intake as a cause. We aimed to define how maternal obesity impacts on early development of the hypothalamus in order to program lasting dysfunction in feeding regulatory pathways. Methods: Mice offspring of diet-induced obese mothers were compared to...
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