High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division.

Tom Owen-Hughes & David Dickerson
In this study we introduce distinct fluorescent tags flanking a range of genomic regions and track the motion of the labelled reporters using an OMX Blaze microscope. We describe a work flow that enables 3D live cell tracking with a mean measurement error of 63 nm. We find that within individual yeast cells the separation of operator sequences exhibits substantial variation over time. Genomic loci are able to reorganize extensively below a threshold of approximately...
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