Timing of gene expression in a cell-fate decision systemAymoz , Solé , Pierre , Schmitt, de Nadal, Posas & Pelet
During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand this process. Pheromone secreted by the mating partner triggers the activity of a MAPK pathway, which results in the expression of hundreds of genes. Using a dynamic expression reporter, we quantified the kinetics of gene expression in single cells upon exogenous pheromone stimulation and in the...
1 citation reported since publication in 2018.
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