Dual spindle formation in zygotes keeps parental genomes apart in early mammalian embryos

Reichmann, Nijmeijer , Hossain , Eguren, Schneider , Politi, Roberti , Hufnagel, Hiiragi & Ellenberg
At the beginning of mammalian life the genetic material from each parent meets when the fertilized egg divides. It was previously thought that a single microtubule spindle is responsible to spatially combine the two genomes and then segregate them to create the two-cell embryo. Utilizing light-sheet microscopy, we showed that two bipolar spindles form in the zygote, which independently congress the maternal and paternal genomes. These two spindles aligned their poles prior to anaphase but...
1 citation reported since publication in 2018.
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