Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells

Benita Wolf, Coralie Busso & Pierre Gönczy
Proper spindle positioning is crucial for spatial cell division control. Spindle positioning in human cells relies on a ternary complex comprising Gαi1-3, LGN and NuMA, which anchors dynein at the cell cortex, thus enabling pulling forces to be exerted on astral microtubules. We developed a live imaging siRNA-based screen using stereotyped fibronectin micropatterns to uncover components modulating spindle positioning in human cells, testing 1280 genes, including all kinases and phosphatases. We thus discover 16 components...
1 citation reported since publication in 2019.
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