3D super-resolution fluorescence microscopy maps the variable molecular architecture of the Nuclear Pore Complex

Jan Ellenberg
We explored the power of 3D super-resolution microscopy combined with computational classification and averaging to explore the 3D structure of the NPC in single human cells. We show that this approach can build the first integrated 3D structural map containing both central as well as peripheral NPC subunits with molecular specificity and nanoscale resolution. Our unbiased classification of over ten thousand individual NPCs indicates that the nuclear ring and the nuclear basket can adopt different...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.