Dynamics of Drosophila endoderm specification

Shannon Keenan
During early Drosophila embryogenesis, a network of gene regulatory interactions orchestrates terminal patterning, playing a critical role in the subsequent formation of the gut. We utilized CRISPR gene editing at endogenous loci to create live reporters of transcription and light-sheet microscopy to monitor the individual components of posterior patterning network across 90 minutes prior to gastrulation. We developed a computational pipeline for fusing imaging datasets of the individual components into a common multivariable trajectory. This...
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