Multi-scale imaging and analysis identifies pan-embryo cell dynamics of germlayer formation in zebrafish

Gopi Shah, Nico Scherf & Jan Huisken
The coordination of cell movements across spatio-temporal scales ensures precise positioning of organs during vertebrate gastrulation. Mechanisms governing such morphogenetic movements have been studied only within a local region, a single germlayer or in whole embryos without cell identity. Scale-bridging imaging and automated analysis of cell dynamics are needed for a deeper understanding of tissue formation during gastrulation. Here we report pan-embryo analyses of formation and dynamics of all three germlayers simultaneously within a developing...
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