Morphological profiling of human T and NK lymphocytes by high-content cell imaging.

Loïc Dupré
The immunological synapse is a complex structure that decodes stimulatory signals into adapted lymphocyte responses. As such, it represents a unique window to monitor lymphocyte activity, owing to the development of systematic quantitative approaches applicable to primary cells. Here we demonstrate the applicability of high-content imaging to human T and NK cells and develop a pipeline for unbiased analysis of high-definition morphological profiles. Our approach reveals how distinct facets of actin cytoskeleton remodeling shape immunological...
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