Delta-9 Fatty Acid Desaturase Mutants Display Increased Body Size

James F.; Savage-Dunn Clark
C. elegans contain three Δ9 fatty acid desaturases (FADs), fat-5, fat-6, and fat-7, responsible for the initial desaturation step in the synthesis of complex polyunsaturated fatty acids (PUFAs). Production of PUFAs is vital for survival, as simultaneous loss-of-function in all three genes results in synthetic lethality (Brock et al. 2006). Animals containing mutations in any one of the three Δ9 FADs, fat-5, fat-6, and fat-7, display an increase in body length. fat-5 mutants display a...
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