Causal Moderation and Mediation Analyses in Multisite Randomized Trials

Xu Qin
An intervention may generate heterogeneous impacts due to natural variations in participant characteristics, context, and local implementation. Important research questions include whether the impact of an intervention is generalizable across individuals and contexts, for whom and under what contexts the intervention is effective, and why. To answer such questions, it is necessary to unpack the mediation mechanism underlying the intervention impact and assess how it varies by individual and contextual characteristics. However, with the existing...
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