Investigating Diacylglycerol Kinase Function and Regulation Using Chemical Proteomics and MassSpectrometry Lipidomics

Roberto Mendez
Diacylglycerol kinases (DGKs) regulate cell metabolism and signaling through poorly defined mechanisms with regards to lipid specificity. My thesis work aims to bridge gaps in our knowledge by investigating isoform-specific functions of DGKs using chemoproteomic and lipidomic methods. We aim to apply novel technologies to explore DGKs to unravel how individual members of this enzyme family can regulate distinct cell biology. We have made progress in determining DGKθ-mediated alterations in the lipidome. These studies have...
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