Quantifying Biophysical Heterogeneity by Single Cell Microfluidic Impedance Cytometry

Armita Salahi
Heterogeneity in biophysical properties, which is inherent to the functional and structural organization of biosystems, presents challenges to cell biologists and clinicians seeking to associate biological function and disease with particular markers. Current methods to quantify heterogeneity focus on biochemical properties, as quantified by single-cell flow cytometry after fluorescent staining for their characteristic cell surface proteins or by label-free Raman spectral methods. Cellular biophysical metrics, on the other hand, have often been restricted to size-based...
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