Identification of MHC-Associated Peptides and Phosphopeptides Presented in Various Diseased Cells by Tandem Mass Spectrometry

Xi Peng
Major histocompatibility complex (MHC) class I and II molecules are involved in the presentation of antigens to T cells, which can initiate an immune response upon recognition of abnormal peptide sequences and modifications. Specifically, phosphopeptides resulting from aberrantly increased protein phosphorylation in cancer are proposed as potential cancer-specific targets for developing novel immunotherapeutic treatments. However, it remains as a challenge to accurately identify these peptide sequences and to localize modification sites due to factors including...
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