The Role of Interferons in Regulating the Subnuclear Positioning of Latent Herpes Simplex Virus Genomes and Reactivation

Jon Suzich
Herpes simplex virus-1 (HSV-1) is a ubiquitous pathogen that establishes lifelong latent infections in post-mitotic neurons, most commonly in the peripheral ganglia. Latent HSV-1 infection is asymptomatic, but the virus periodically reactivates, which can lead to significant disease, including a life-threatening encephalitis or recurrent HSV-1 ocular infection, a leading cause of infectious blindness worldwide. Recent evidence suggests that recurrent HSV-1 infection may also impact the progression of Alzheimer’s disease. Therefore, there is a need to...
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