The role of Notch signaling in regulating neural stem cell quiescence and termination during development

Chhavi Sood
Multipotent cells called neural stem cells (NSCs) proliferate to produce a functional adult neural circuitry and maintain tissue homeostasis during development and in adulthood. NSCs can divide either symmetrically to increase stem cell numbers or asymmetrically to produce different types of progenies. During development, most NSCs terminate their proliferation and neurogenesis becomes restricted and in the adult tissue, NSCs are maintained in a state of quiescence in neurogenic niches. The NSC proliferation versus quiescence decisions...
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