A High-Throughput Analytic Strategy for Discovery of Molecular Targeting Ligands for Pancreatic Diseases

Jessica Hung
Pancreatic diseases are worldwide public health issues and account for substantial health care utilization and spending. Thus far, effective therapeutic options remain limited. The emergence of proteomic technologies has improved our understanding of differential protein expression in chronic pancreatitis (CP) and pancreatic cancer. Yet, developing target-specific interventions based on proteomic profiles will require significant improvement in the methodologies to generating targeting moieties. In this dissertation, we explore phage display as a method for selecting molecular...
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