A systems immunology investigation of pregnancy immune phenotypic differences between racial groups

Remziye Erdogan
In the United States the non-Hispanic black (NHB) infant mortality rate is more than twice the non-Hispanic white (NHW) rate. Further, NHB infants of US-born mothers have statistically worse birth outcomes than infants born to first-generation US immigrants from Africa, indicating trans-generational influences beyond genetics (epigenetics) that impact neonatal health. A successful pregnancy requires a series of well-timed immunological events to support fetal growth and maintain fetal tolerance, including the balance of pro- and anti-inflammatory...
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