Designing Spatiotemporally Tunable Viscoelastic Hyaluronic Acid Hydrogels to Study Cell Mechanobiology During Fibrosis

Erica Hui
The ECM is highly dynamic and is constantly regulated through cell-cell and cell-matrix interactions. ECM dysregulation can trigger various signaling cascades and promote deviant cell behaviors and disease progression. Fibrosis is a heterogeneous pathological scarring outcome of many diseases that is characterized by progressive matrix stiffening and decreasing viscoelasticity. Treatments have been largely unsuccessful due to a lack of suitable test systems for probing molecular mechanisms involved in fibrogenesis. Additionally, most hydrogel models fail to...
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