Elucidating conformational changes in Syntaxin-1a on different stages of SNAREsassembly using Electron Paramagnetic Resonance

Vanessa Bijak
When an action potential arrives at the axon terminal, it causes a local increase in intracellular Ca2+ concentration that starts a cascade of molecular interactions leading to the fusion of synaptic vesicles with the plasma membrane. This process is called neuronal exocytosis and is mediated by SNARE proteins. SNAREs are a highly conserved group of proteins that interact to form a coiled-coil assembly called the SNARE complex. The assembly of this complex is believed to...
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