Non-invasive single cell imaging in bacterial biofilms under controlled physicochemical environments

Ji Zhang
Bacteria commonly live in dense and diverse communities, known as biofilms. As the major mode of microbial life, biofilms have been widely recognized for their impact on global biogeochemical cycling and the health of higher living organisms. Commonly used assays to study biofilm probe biofilm formation and behavior using ensemble averaged data. However, to better understand how the individual behaviors of biofilm dwelling cells contribute to the emergent macroscopic properties of biofilms, cellular level information...
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