Development of an Agent-Based Model to Investigate Long-term Disease Progression in Duchenne Muscular Dystrophy

Katherine Crump
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease that affects 1 in every 3,500 boys. Patients with DMD require a wheelchair by age 12, and ultimately die due to respiratory or cardiac failure by the mid 20s. The initiating cause of DMD is known – the absence of dystrophin, a protein that associates with a multimolecular network of integral and subsarcolemmal proteins, known as the dystrophin glycoprotein complex (DGC). Dystrophin and the DGC...
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