Cell Type-Selective Regulation of Food Intake and Novelty Driven Investigatory Behavior by Neurons of the Mouse Medial Prefrontal Cortex

Brandon Newmyer
The prefrontal cortex controls food reward seeking and ingestion, playing important roles in directing attention, regulating motivation toward reward pursuit, and assigning reward salience and value. The cell types that mediate these behavioral functions, however, are not well described. We report here that optogenetic activation of vasoactive intestinal peptide–expressing (VIP-expressing) interneurons in both the infralimbic (IL) and prelimbic (PL) divisions of the medial prefrontal cortex in mice is sufficient to reduce acute, binge-like intake of...
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