Enrichment and identification of phosphorylated and glycosylated MHC-I peptides from clinical tumor samples and murine models

Mohammad Ovais Azizzanjani
Despite extensive research, cancer is the second cause of death globally and in the USA. In the past decade, the immune checkpoint blockade (ICB) therapies with antibodies that target T cell checkpoint protein have revolutionized cancer treatment. However, the ICB is not selective and tumor responses vary, suggesting the importance of identifying cancer neoantigens to develop targeted immunotherapies. Previous studies in the Hunt lab revealed that a deregulated cell signaling in cancer results in the...
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